Kagawa Nutrition University
Kazuhiko Yamada, Ph.D.
Outline of Research Activities

We are studying the digestion, absorption and fermentation of dietary carbohydrates in the gut, in according to the biochemical and nutritional viewpoints as a basis. The gut is the organ which takes a food and discharges a residual, with the situation in which, a high molecular compound of meal origin is digested and absorbed while resolving an order into low molecular. At the same time, it is also the organ which touches an external environment widely in the bowels of the body. We are focusing the response to the meal environment on several digestive enzymes such as sucrase, lactase or trehalase in the microvillus membrane of small intestine, in particular.
We also participate in the food and nutrient labeling system of health claims on scientific evidence in Japan such as the foods with nutrient function claims and foods for specified health uses (FOSHU).

Recent Publications

Nagata, J. and Yamada, K.: Effects of simultaneous intakes of soybean protein and diacylglycerol on lipid profiles and body fat accumulation in rats. Biosci. Biotechnol. Biochem., 73, 1328-1332 (2009)

Yamada, K., Sato-Mito, N., Nagata, J. and Umegaki, K. : Health claim evidence requirements in Japan. J. Nutr., 138, 1192S-1198S (2008)(review)

Takebayashi, J., Nagata, J. and Yamada, K..: Improved analytical precision of 1,4-dihydroxy-2-naphthoic acid by high performance liquid chromatography using dithiothreitol as mobile phase additive. Food Science and Technology Research, 14, 509-512 (2008)

Fujioka, M., Sudo Y., Okumura, M., Wu J., Uehara, M., Takeda, K., Hosokawa, Y., Yamada, K., Ikegami, S. and Ishimi, Y. Differential effects of isoflavones on bone formation in growing male and female mice. Metabolism, 56, 1142-1148 (2007)

Fujioka M., Sudo Y., Okumura M., Wu J., Uehara M., Takeda K., Hosokawa Y., Yamada K, Ikegami S., and Ishimi Y.: Differential effects of isoflavones on bone formation in growing male and female mice. Metabolism. 56, 1142-1148(2007)

Gotoh H., Harada K., Suzuki K., Hashimoto S., Yamamura H., Sato T., Fukumoto K., Hagiwara H., Ishida T., Yamada K., Asano R. and Yano T. Expression patterns of connexin 26 and connexin 43 mRNA in canine benign and malignant mammart tumours. Vet J: 172, 178-180(2006)

Ishida T., Yokota A., Umezawa Y., Toda T. and Yamada K. Identification and characterization of lactococcal and Acetobacter strains isolated from traditional Caucasusian fermented milk. : J Nutr Sci Vitaminol (Tokyo). 51, 187-193(2005)

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